Frank and his best friend go about their morning routine ("Who’s the Guy?"), but their day quickly unravels, for the friend is none other than Neurosis, Frank’s anxieties personified in a character only he can see. Samantha, a therapist and our narrator, explains to us that, like Frank, everyone has a neurosis ("You Got Neurosis").

During lunch, Frank visits his parents. They’re dismissive of his job working at a magic shop, but Frank is excited because he’s just been accepted into the Legends of Magic showcase. At last, he will be "Incredible Frank."

Meanwhile, Abby, a successful marketing executive, has been dumped by yet another jerk. Receiving little consolation from Neurosalina, her neurosis, Abby commits to finding a guy who’s actually nice ("Make Him Mine").

At the magic shop, Frank’s boss steals his invitation to Legends of Magic. This sends him into a breakdown ("Incredible Frank – Reprise") and straight to therapy. Samantha, his therapist, delivers an ultimatum: be in the moment or fail at life ("No Easy Answers"). Attempting to follow her advice, Frank goes to a party where he meets Abby, but with Neurosis as his wingman, he crashes and burns ("Use Your Words"). For an alternative to therapy, Neurosis brings Frank to his parents, who offer their own solution for Frank’s faltering life ("Law School").

A few days later, as Neurosalina psychs up Abby for a night on the town ("You Got What It Takes"), Frank goes back to therapy. Samantha reveals she can see Neurosis and suggests that he’s to blame for Frank’s problems ("Who’s the Guy – Reprise"). Frank refuses to consider this. However, that night at the bar, Frank successfully flirts with Abby and finally manages to shut out Neurosis by drinking him away ("Let Go").

Three weeks later, Abby and Frank are in a serious relationship ("Boyfriend-Girlfriend"), and Neurosis and Neurosalina are seriously displeased ("Well, Goodnight"). These tensions culminate in a disastrous dinner with Frank’s parents ("Meet-the-Parents Tango"), and Abby breaks up with Frank.

Miserable, Frank blames Neurosis and ends their friendship. Now without Abby or Neurosis, for the first time in his life, Frank is truly alone ("When You’re Alone"). When Frank hits rock bottom, Neurosis brings him to Samantha’s office for couple’s therapy, and they finally come to terms with each other ("You Are My Neurosis"). Now, Frank just needs to mend his relationship with Abby. To do so, Frank and Abby commit the ultimate act of trust— showing each other their Neuroses ("Boyfriend-Girlfriend – Reprise").

With everyone’s relationships newly restored and finally functional, Samantha, joined by the cast, wraps up the show ("Rock Your Neurosis").